To achieve plasma concentrations of januvia similar to those in patients with normal renal function, lower dosages are recommended in patients with moderate and severe renal insufficiency, as well as in esrd patients requiring dialysis.
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the national institutes of health says that januvia, or sitagliptin, stimulates insulin secretion when high blood sugar is present and inhibits glucagon secretion.
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januvia lowers blood sugar when blood sugar is high, especially after a meal.
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januvia has been successful in clinical trials at helping to lower them when traditional methods aren t enough.
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Januvia demonstrates selectivity for dpp-4 and does not inhibit dpp-8 or dpp-9 activity in vitro at concentrations approximating those from therapeutic doses.
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