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Due to individual variability in response to antipsychotics, it may be prudent to continue the existing regimen if ongoing treatment is deemed necessary during breast-feeding, however, alternate medications for consideration include atypical agents such as olanzapine or quetiapine.

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MAIN RESULTSTwenty trials are includedAttrition from olanzapine versus placebo studies was so greatolanzapine61placebo73by six weeksRR 0.85 CI 07-0.98NNT 8 CI 5-40that interpretation of results is problematicOlanzapine appeared superior to placebo at six weeks for the outcome ofno important clinical responseRR 0.88 CI 0.8-0.98NNT 8 CI 5-27but trial data regarding negative symptoms are equivocal for this comparisonDizziness and dry mouth were more common in the olanzapine-treated groupandalthough not statistically significantthe olanzapine group gained more weightData from several small trials are incompletebutfor the short term outcome ofno important clinical responseolanzapine seem as effective as typical antipsychoticsn=2778RR 0.9 CI 0.76-1.06Brief Psychiatric Rating ScaleBPRSdata tended to be equivocal but Positive and Negative Syndrome ScalePANSSrating of total score and negative and positive symptom sub-scores favoured olanzapineWith high attrition in both groupsolanzapine36typical drug49by 6 weeksn=2738RR 0.85 CI 0.66-1.1olanzapine83typical drug90by 1 yearn=2738RR 0.9 CI 086-1.02the assumptions included in all continuous data are considerableParticipants us online pharmacy medicines. allocated olanzapine experienced fewer extrapyramidal side effects than people given haloperidolWeight change data for the short term are not conclusiven=2455WMD 0.8kg CI0.6-2.2but the three to 12 month results suggest an average gain of four kilogramsn=233WMD 4 CI 0.3-7.8It is difficult to distinguish between olanzapine and other atypical drugsalthough it may cause fewer extrapyramidal side effects than risperidonen=339RR 0.6 CI 0.4-0.9NNH 8 CI 4-29Olanzapine did cause more weight gain than its comparators but current data are not statistically significant3-12 monthsn=535WMD 2.2kg CI0.6-5One studyn=180found no clear differences between olanzapine and clozapine for people with treatment-resistant illness.

AgitationOverallthere was no difference in the incidence of discontinuation due to adverse reactions0.4for intramuscular olanzapine for injection vs 0for placebo

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Aims & Objectives

To support an intelligent debate on Scotland's constitutional future by providing timely evidence and rigorous analysis of the issues in the debate on Scottish Independence.

To turn Scotland from an economy which relies on an ever-dwindling supply of resources to a sustainable economy which relies on resources which will still be available for future generations .

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With a PhD from the University of Cambridge, Dr Ibrahim is highly in demand for his expertise in the area of geopolitical strategy. He has advised many world leaders in recent years and served as an International Security Fellow at Kennedy School of Government at Harvard, a World Fellow at Yale and an Adjunct Research Professor at the Strategic Studies Institute, US Army War College.

Dr Ibrahim also founded over half a dozen award-winning companies in three continents, including his most recent venture, Ibrahim Associates - a non-profit global strategic consultancy firm. His many years of experience as an economic expert led him to consider the situation of his own home country. He knew that innovative policy solutions were required if Scotland was to remain globally competitive, and he responded to this need by setting up The Scotland Institute.
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Corrine was also awarded a scholarship and worked/studied at Oregon State University in the United States for 3 months where she facilitated contacts for the Oregon State University representatives who were travelling to Orkney to meet with European Marine Energy Centre with the purpose of gaining information to assist in setting up a marine testing bay in Oregon. Ultimately this resulted in talks between two Universities in holding joint Masters Programmes.

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