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Frequency not reportedHyponatremiahypomagnesemiahypocalcemiahypokalemiaRef]
Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
In patients with mild to severe hepatic impairmentChild-Pugh Class A to Cmaximum pantoprazole concentrations increased only slightly1.5-foldrelative to healthy subjects when pantoprazole sodium was administered orallyAlthough serum half-life values increased to 7 to 9 hours and AUC values increased by 5to 7-fold in hepatic-impaired patientsthese increases reviews on nizoral cream. were no greater than those observed in CYP2C19 poor metabolizerswhere no dosage adjustment is warrantedThese pharmacokinetic changes in hepatic-impaired patients result in minimal drug accumulation following once-dailymultiple-dose administrationOral pantoprazole doses higher than 40 mg per day have not been studied in hepatically impaired patients.
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