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Cardiovascular Thrombotic Eventssee WARNINGS AND PRECAUTIONSGI BleedingUlceration and Perforationsee WARNINGS AND PRECAUTIONSHepatotoxicitysee WARNINGS AND PRECAUTIONSHypertensionsee WARNINGS AND PRECAUTIONSHeart Failure and Edemasee WARNINGS AND PRECAUTIONSRenal Toxicity and Hyperkalemiasee WARNINGS AND PRECAUTIONSAnaphylactic Reactionssee WARNINGS AND PRECAUTIONSSerious Skin Reactionssee WARNINGS AND PRECAUTIONSHematologic Toxicitysee WARNINGS AND PRECAUTIONS
CELEBREXcelecoxibcapsule is a nonsteroidal anti-inflammatory drugavailable as capsules containing 50 mg100 mg200 mg and 400 mg celecoxib for oral administrationThe chemical name is 454-methylphenyl3trifluoromethyl1H-pyrazol-1-ylbenzenesulfonamide and is a diaryl-substituted pyrazoleThe molecular weight is 381.38Its molecular formula is C 17 H 14 F 3 N 3 O 2 Sand it has the following chemical structure:
Celecoxib and anticoagulants such as warfarin have a synergistic effect on bleedingThe concomitant use of Celecoxib and anticoagulants have an increased risk of serious bleeding compared to the use of either drug aloneSerotonin release by platelets plays an important role in hemostasisCase-control and cohort epidemiological studies showed that concomitant use of drugs that interfere with serotonin reuptake and an NSAID may potentiate the risk of bleeding more than an NSAID alone.
In acute analgesic models of post-oral surgery painpost-orthopedic surgical painand primary dysmenorrheaCELEBREX relieved pain that was rated by patients as moderate to severeSingle dosessee DOSAGE AND ADMINISTRATIONof CELEBREX canadian pharmacy no prescription xanax. provided pain relief within 60 minutes.
The sulfato de amantadina. correlation between findings of short-term endoscopic studies with CELEBREX and the relative incidence of clinically significant serious upper GI events with long-term use has not been establishedSerious clinically significant upper GI bleeding has been observed in patients receiving CELEBREX in controlled and open-labeled trialssee WARNINGS AND PRECAUTIONS and Clinical Studies
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