Prazosin should be used during pregnancy only if the potential benefit justifies the potential risk to the mother and the unborn baby.
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in the human prostate, prazosin antagonizes phenylephrine alpha1 agonist -induced contractions, in vitro , and binds with high affinity to the alpha1c adrenoceptor, which is thought to be the predominant functional type in the prostate.
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although clinical experience is limited, prazosin has been administered concomitantly with digoxin without any apparent adverse interaction.
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in chronic studies one year or more of prazosin hydrochloride capsules in rats and dogs, testicular changes consisting of atrophy and necrosis occurred at 25 mg kg day 75 times the usual maximum recommended human dose .
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