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This drug may rarely cause seriousrarely fatalliver diseaseIf you notice any of the following rare but serious side effectsseek immediate medical attentionpersistent nausea/vomitingsevere stomach/abdominal painyellowing eyes/skindark urine.
The metabolism of labetalol is mainly through conjugation to glucuronide metabolitesThese metabolites are present in plasma and are excreted in the urine andvia the bileinto the fecesApproximately sexpowar, sexpowar, sexpowar, sexpowar, sexpowar, sexpowar. 55to 60of a dose appears in the urine as conjugates or unchanged labetalol within the first 24 hours of dosing.
If rapid reduction of blood pressure is necessarysee the SPC for Trandate InjectionIf long-term control of hypertension following the use of Trandate Injection is requiredoral therapy with Trandate tablets should start with 100mg twice dailyAdditive hypotensive effects may be expected if Trandate tablets are administered together with other antihypertensives e.gdiureticsmethyldopa etcWhen transferring patients from such agentsTrandate tablets should be introduced with a dosage of 100mg twice daily and the previous therapy gradually decreasedAbrupt withdrawal of clonidine or beta-blocking agents is undesirable.
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do not take any other medicines while you are taking trandate, without first talking to your doctor.