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The excretion of chloroquine and the major metabolitedesethylchloroquinein breast milk was investigated in eleven lactating mothers following a single oral dose of chloroquine600 mg baseThe maximum daily dose of the drug that the infant can receive from breastfeeding was about 0.7of the maternal start dose of the drug in malaria chemotherapySeparate chemoprophylaxis for the infant is requiredSee DOSAGE AND ADMINISTRATION.

Chloroquine causes a toxic myopathy but also produces a toxic neuropathyChloroquine is an antimalarial drug also used for the treatment of severe rheumatoid arthritissystemic lupus erythematosusand other dermatological diseasesThe clinical features of chloroquineinduced neuropathy are kegunaan amoxicillin tablet 216, kegunaan amoxicillin tablet 216, kegunaan amoxicillin tablet 216, kegunaan amoxicillin tablet 216, kegunaan amoxicillin tablet 216, kegunaan amoxicillin tablet 216. those of symmetrical sensorimotor polyneuropathyBoth axonal damage and primary demyelination have been reportedA prominent pathological feature of chloroquine neuropathy is ultrastructural intracytoplasmatic lamellar inclusionsresembling those described in amiodarone neuropathywithin Schwann cells and in perineurial and endothelial cells but not in axonsOnly long-term treatment has been associated with chloroquine neuropathyfollowed by complete recovery after drug withdrawal.

If there is any indicationpast or presentof abnormality in the visual acuityvisual fieldor retinal macular areassuch as pigmentary changesloss of foveal reflexor any visual symptomssuch as light flashes and streakswhich are not fully explainable by difficulties of accommodation or corneal opacitiesthe drug should be discontinued immediately and the patient closely observed for possible progressionRetinal changesand visual disturbancesmay progress even after cessation of therapy.

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To support an intelligent debate on Scotland's constitutional future by providing timely evidence and rigorous analysis of the issues in the debate on Scottish Independence.

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