The three primary efficacy comparisons were i non-inferiority of atrovent 20 100 mcg to cfc-propelledcombivent inhalation aerosol 36 206 mcg for the fev 1 auc 0-6h on test day 85; ii superiorityof atrovent 20 100 mcg to atrovent respimat 20 mcg for the fev 1 auc 0-4h on test day 85, to demonstrate the contribution of albuterol inthe combination product, and iii non-inferiority of combivent respimat 20 100 mcg in comparison to atrovent respimat 20 mcg for fev 1 auc 4-6h on test day 85, to demonstratethe contribution of atrovent in the combination product.
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caution is advised in the coadministration of combivent respimat and other sympathomimetic agents due to the increased risk of adverse cardiovascular effects see warnings and precautions 5.
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