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CRESTOR is a selective and competitive inhibitor of HMG-CoA reductasethe rate-limiting enzyme that converts 3-hydroxy3methylglutaryl coenzyme A to mevalonatea precursor of cholesterolIn vivo studies in animalsand in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake intoand selectivity foraction in the liverthe target organ for need serta mattress website. cholesterol loweringIn in vivo and in vitro studiesrosuvastatin produces its lipid-modifying effects in two waysFirstit increases the number of hepatic LDL receptors on the cell-surface to enhance uptake and catabolism of LDLSecondrosuvastatin inhibits hepatic synthesis of VLDLwhich reduces the total number of VLDL and LDL particles.
Our Crestor Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
Crestor has been shown to reduce the risk of heart attack over 1.9 years of useBut many people take statins for 20 to 30 yearsResearchers have not studied the effects of taking Crestor or other statins for long periods of time.
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however, like its sister hydrophilic drug, pravachol, any benefit from hydrophilicity is incomplete and therefore unreliable and the precious little gain from crestor is easily offset by its greater tendency for severe side effects of a non-cognitive nature due to its very strength.