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The apparent volume of distribution of pantoprazole is approximately 11 to 23.6 Ldistributing mainly in extracellular fluidThe alli diet pills from canada. serum protein binding of pantoprazole is about 98primarily to albumin.
Clopidogrel is metabolized to its active metabolite in part by CYP2C19In a crossover clinical study66 healthy subjects were administered clopidogrel300 mg loading dose followed by 75 mg per dayalone and with oral pantoprazole80 mg at the same time as clopidogrelfor 5 daysOn Day 5the mean AUC of the active metabolite of clopidogrel was reduced by approximately 14geometric mean ratio was 86with 90CI of 79 to 93when pantoprazole sodium was coadministered with clopidogrel as compared to clopidogrel administered alonePharmacodynamic parameters were also measured and demonstrated that the change in inhibition of platelet aggregationinduced by 5 micromolar ADPwas correlated with the change in the exposure to clopidogrel active metaboliteThe clinical significance of this finding is not clear.
Administration of oral pantoprazole 40 mg twice daily for 4 days and a single 1000 mg dose of MMF approximately one hour after the last dose of pantoprazole to 12 healthy subjects in a cross-over study resulted in a 57reduction in the C max and 27reduction in the AUC of MPATransplant patients receiving approximately 2000 mg per day of MMFn=12were compared to transplant patients receiving approximately the same dose of MMF and oral pantoprazole 40 mg per dayn=21There was a 78reduction in the C max and a 45reduction in the AUC of MPA in patients receiving both pantoprazole and MMFsee Drug Interactions7
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the active ingredient in protonix pantoprazole sodium .