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One hundred forty-four hypertensive pediatric patients aged 6 to 16 years were randomized to placebo or to one of three dose levels of TOPROL-XL0.21.0 or 2.0 mg/kg once dailyand followed for 4 weeksThe study did not meet its primary endpointdose response for reduction in SBPSome pre-specified secondary endpoints demonstrated effectiveness including:
These are serious side effectsYou may need urgent medical attentionSerious side effects are rare.
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peak plasma concentrations c max of metoprolol and hydrochlorothiazide occur within 10-12 hours and 2 hours of dose intake, respectively.