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In a study of 26 weeks duration702 patients were randomized to doses of 3 mg6 mgor 9 mg per day of EXELON or to placeboeach given in divided dosesThe fixed-dose study designwhich included a 12-week forced-dose ez online pharmacy buy cialis usa. titration phase and a 14-week maintenance phaseled to a high dropout rate in the 9 mg per day group because of poor tolerabilityAt 26 weeks of treatmentsignificant differences were observed for the ADAS-cog mean change from baseline for the 9 mg per day and 6 mg per day groupscompared to placeboNo significant differences were observed between any of the EXELON-dose groups and placebo for the analysis of the CIBIC-Plus mean rating of changeAlthough no significant differences were observed between EXELON treatment groupsthere was a trend toward numerical superiority with higher doses.
Although the precise mechanism of action of rivastigmine is unknownit is thought to exert its therapeutic effect by enhancing cholinergic functionThis is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by cholinesteraseThereforethe effect of rivastigmine may lessen as the disease process advances and fewer cholinergic neurons remain functionally intactThere is no evidence that rivastigmine alters the course of the underlying dementing process.
The rate of discontinuation due to adverse events in the single placebo-controlled trial of EXELON was 18for patients receiving 3 mg to 12 mg per day compared to 11for patients on placebo viagra boots. during the 24-week study.
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