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Fucidin is useful againstantibiotic-resistant staphylococciwhich are a major problem in causing shunt site infections in patients on chronic intermittent haemodialysis for end-stage renal failureA new form of intravenous fucidin has been used in vivo in three patients on haemodialysisand also in experiments in vitro in order to assess its dialysing propertiesThe experiments in vitro show that some fucidin does cross the dialyser membrane butin the patients studiedadequate serum levels were maintained throughout a 10-hour haemodialysisA single intravenous dose of Fucidin isthereforeadequate for treatingantibiotic-resistantstaphylococcal infections in patients during haemodialysis.
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the most frequently reported undesirable effects to fucidin administered orally are dose dependent gastrointestinal disorders.