The rate of spontaneous abortion in the priftin isoniazid arm 15 , and the rate of spontaneous abortion in the isoniazid arm 19 , did not represent an increase over the background rate of 15 to 20 percent reported in the general population.
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rifampin could be 17 less efficacious than self-administered isoniazid and still be cost-saving compared with this regimen.
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1964 isoniazid, para-aminosalicylic acid and streptomycin intolerance in 1744 patients.
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during the 4 month continuation phase, 317 patients in the priftin group continued to receive priftin 600 mg dosed once-weekly with isoniazid and 304 patients in the rifampin group received twice weekly rifampin and isoniazid.
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however, it is unclear if these regimens are appropriate for high burden settings, as research has shown that in settings with high rates of tb transmission, the benefits of isoniazid preventive therapy last only as long as the treatment itself.
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Cobimetinib is a cyp3a substrate in vitro, and isoniazid is a moderate inhibitor of cyp3a.
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