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Tumos w obsvd in th uinay bladd mal ats in th two-ya cacinognicity study [s Nonclinical Toxicology ]. In addition, duing th th ya POactiv clinical tial, 14 patints out 2605 (0.54%) andomizd tACTOS and 5 out 2633 (0.19%) andomizd tplacbw diagnosd with bladd canc. At xcluding patints in whom xposu tstudy dug was lss than on ya at th tim diagnosis bladd canc, th w 6 (0.23%) cass on ACTOS and tw(0.08%) cass on placbo. At compltion th tial, a lag subst patints was obsvd up t10 additional yas, with littl additional xposu tACTOS. Duing th 13 yas both POactiv and obsvational ollow-up, th occunc bladd canc did not di btwn patints andomizd tACTOS placb(H =1.00; [95% CI: 0.59-1.72]).
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5-tims th 45 mg clinical dos), but dlayd patuition and ducd mbyotal viability at 40 and 80 mg/kg, ?9-tims th 45 mg clinical dos, by body suac aa. In pgnant abbits administd pioglitazon duing oganognsis, nadvs dvlopmntal cts w obsvd at 80 mg/kg (
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