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Methylprednisolonea potent anti-inflammatory steroid synthesized and developed in the Research Laboratories of The Upjohn Company is the 6-methyl derivative of prednisoloneIt has a greater anti-inflammatory potency than prednisolone and even less tendency than prednisolone to induce sodium and water retentionIts advantage over the older corticoids lies in its ability to achieve equal anti-inflammatory effect with lower dosewhile at the same time enhancing the split between anti-inflammatory and mineralocorticoid activities.
These preparations are recommended for intramuscular and intrasynovial injection in horses and dogsand intramuscular injection in catsDEPO-MEDROL Sterile Aqueous Suspension is available in two concentrations20 mg per mL and 40 mg per mL.
Because of its inhibitory effect on fibroplasiamethylprednisolone may mask the signs of infection and enhance dissemination of the infecting organismHenceall animal patients receiving methylprednisolone should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by use of appropriate antibacterial measuresor administration of methylprednisolone should be discontinued.
Applies to methylprednisolonecompounding powderinjectable powder for injectioninjectable suspensionoral tablet.
With therapeutically equivalent dosesthe likelihood of occurrence of troublesome side effects is less with methylprednisolone than with prednisolonemoreoverside effects actually have been conspicuously absent during clinical trials with MEDROL Tablets in dogs and catsHowevermethylprednisolone is similar to prednisolone in regard to kinds of side effects and metabolic alterations to be anticipated when treatment is intensive or prolongedIn animal patients with diabetes mellitususe of methylprednisolone may be associated with an increase in 24 hour viagra. the insulin requirementNegative nitrogen balance may occurparticularly in animals that require protracted maintenance therapymeasures to counteract persistent nitrogen loss include a high protein intake and the administration when indicatedof a suitable anabolic agentExcessive loss of potassiumlike excessive retention of sodiumis not likely to be induced by effective maintenance doses of MEDROLHoweverthese effects should be kept in mind and the usual regulatory measures employed as indicatedEcchymotic manifestationswhile not noted during the clinical evaluation in dogs and catsmay occurIf such reactions do occur and are seriousreduction in dosage or discontinuance of methylprednisolone therapy may be indicatedConcurrent use of daily oral supplements of ascorbic acid may be of value in helping to control ecchymotic tendencies.
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