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The major metabolite of glyburide is the 4-transhydroxy derivativeA second metabolitethe 3-cishydroxy derivativealso occursThese metabolites probably contribute no significant hypoglycemic action in humans since they are only weakly active1/400th and 1/40th as activerespectivelyas glyburidein rabbitsGlyburide is excreted as metabolites in the bile and urineapproximately 50by each routeThis dual excretory pathway is qualitatively different from that of other sulfonylureaswhich are excreted primarily in the urine.
Take Micronase by mouth with food as directed by your doctorIf you are taking 1 dose dailytake Micronase with breakfast or the first main meal of the day unless your doctor tells you otherwiseHigh amounts of dietary amoxicillin online viagra. fiber may decrease Micronase’s effectivenessresulting in high blood sugarIf you have questions about fiber in your diet while you are taking Micronasetalk with your doctorIf you also take colesevelamtake Micronase at least 4 hours before your dose of colesevelamCheck with your doctor if you have questionsMicronase works best if it is taken at the same time each dayContinue to take Micronase even if you feel wellDo not miss any dosesIf you miss a dose of Micronasetake it as soon as possibleIf it is almost time for your next doseskip the missed dose and go back to your regular dosing scheduleDo not take 2 doses at once.
If you have any questions about Micronaseplease talk with your doctorpharmacistor other health care providerMicronase is to be used only by the patient for whom it is prescribedDo not share it with other peopleIf your symptoms do not improve or if they become worsecheck with your doctorCheck with your pharmacist about how to dispose of unused medicine.
Prolonged severe hypoglycemia4 to 10 dayshas been reported in neonates born to mothers who were receiving a sulfonylurea drug at the time of deliveryThis has been reported more frequently with the use of agents with prolonged half-livesIf MICRONASE is used during pregnancyit should be discontinued at least two weeks before the expected delivery date.
Stop taking this medication and call your doctor at once if you have any of these serious side effects:
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