Mutagenesis — no evidence of mutagenic potential for olanzapine was found in the ames reverse mutation test, in vivo micronucleus test in mice, the chromosomal aberration test in chinese hamster ovary cells, unscheduled dna synthesis test in rat hepatocytes, induction of forward mutation test in mouse lymphoma cells, or in vivo sister chromatid exchange test in bone marrow of chinese hamsters.
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electrophysiological studies demonstrated that olanzapine selectively reduced the firing of mesolimbic a10 dopaminergic neurons, while having little effect on the striatal a9 pathways involved in motor function.
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during premarketing clinical studies of zyprexa relprevv, adverse events that presented with signs and symptoms consistent with olanzapine overdose, in particular, sedation including coma and or delirium, were reported in patients following an injection of zyprexa relprevv see boxed warning and dosage and administration 2.
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For people with treatment-resistant illness there were no clear differences between olanzapine and clozapine 4 rcts , buy vermox without prescription. n 457 .
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