Adverse reactions occurring at an incidence of 2 or more among oral olanzapine-treated patients in short-term, placebo-controlled trials.
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Elderly patients with dementia related psychosis treated with antipsychotics are at an increased risk of death.
Bipolar I DisorderManic or Mixed EpisodesOlanzapine as Adjunct to Lithium or ValproateIn a study of patients who were already tolerating either lithium or valproate as monotherapydiscontinuation rates due to adverse reactions were 11for the combination of oral olanzapine with lithium or valproate compared to 2for patients who remained on lithium or valproate monotherapyDiscontinuations with the combination of oral olanzapine and lithium or valproate that occurred in more than 1 patient weresomnolence3weight gain1and peripheral edema1
Olanzapine enters breast milkit is not recommended for use while breastfeeding.
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tizanidine moderate tizanidine should be used cautiously and with close monitoring with olanzapine.