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Measures are depending on the time of medicinal product intake and kind and severity of symptomsStabilisation of the cardiovascular system should be given priorityAfter oral intakethe administration of a sufficient dose of activated charcoal is indicatedAfterwardsclose monitoring of the vital parameters should be performedVital parameters should be corrected if necessary.
Losartan does not have an agonist effect nor does it block other hormone receptors or ion channels important in cardiovascular none prescribtion drug canada abalify, none prescribtion drug canada abalify, none prescribtion drug canada abalify, none prescribtion drug canada abalify, none prescribtion drug canada abalify, none prescribtion drug canada abalify. regulationFurthermore losartan does not inhibit ACEkininase IIthe enzyme that degrades bradykininConsequentlythere is no potentiation of undesirable bradykinin-mediated effects.
A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
Losartan is predominantly metabolised by cytochrome P450CYP2C9 to the active carboxy-acid metaboliteIn a clinical trial it was found that fluconazoleinhibitor of CYP2C9decreases the exposure to the active metabolite by approximately 50It was found that concomitant treatment of losartan with rifampicininducer of metabolism enzymesgave a 40reduction in plasma concentration of the active metaboliteThe clinical relevance of this effect is unknownNo difference in exposure was found with concomitant treatment with fluvastatinweak inhibitor of CYP2C9
Some antihypertensive drugs have smaller blood pressure effectsas monotherapyin black patientsand many antihypertensive drugs have additional approved indications and effectse.gon anginaheart failureor diabetic kidney diseaseThese considerations may guide selection of therapy.
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