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In a study conducted in healthy volunteersthe concomitant administration of repaglinidea single dose of 0.25 mgand ciclosporinrepeated dose at 100 mgincreased repaglinide AUC and C max about 2.5-fold and 1.8-fold respectivelySince the interaction has not been established with dosages higher than 0.25 mg for repaglinidethe concomitant use of ciclosporin with repaglinide should be avoidedIf the combination appears necessarycareful clinical and blood glucose monitoring should be performedsee section 4.4
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