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Malabsorption is occasionally noted in patients with hypoparathyroidismhencelarger doses of Rocaltrolcalcitriolmay be needed.
Calcitriol from ingested Rocaltrolcalcitriolmay be excreted in human milkBecause many drugs are excreted in human milk and because of the potential for serious adverse reactions from Rocaltrolcalcitriolin nursing infantsa mother should not nurse while taking Rocaltrolcalcitriol
In the rabbitdosages of 0.3 mcg/kg/dayapproximately 6 times maximum recommended dose based on surface areaadministered on days 7 to 18 of gestation resulted in 19maternal mortalitya decrease in mean fetal body weight and a reduced number of newborn surviving to 24 hoursA study of perinatal and postnatal development in rats resulted in hypercalcemia in the offspring of dams given Rocaltrolcalcitriolat doses of 0.08 or 0.3 mcg/kg/dayapproximately 1 and 3 times the maximum recommended dose based on mg/m 2hypercalcemia and hypophosphatemia in dams given Rocaltrolcalcitriolat a dose of 0.08 or 0.3 mcg/kg/dayand increased serum urea nitrogen in dams given Rocaltrolcalcitriolat a dose of 0.3 buying cialis in ireland. mcg/kg/dayIn another study in ratsmaternal weight gain was slightly reduced at a dose of 0.3 mcg/kg/dayapproximately 3 times the maximum recommended dose based on mg/m 2administered on days 7 to 15 of gestationThe offspring of a woman administered 17 mcg/day to 36 mcg/day of Rocaltrolcalcitriolapproximately 17 to 36 times the maximum recommended doseduring pregnancy manifested mild hypercalcemia in the first 2 days of life which returned to normal at day 3.
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