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20Schumacher YOZdebik AHuonker MKreisel WSildenafil in HIV-related pulmonary hypertensionAIDS 1520011747-8.
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A 65-year-old male with hereditary hemorrhagic telangiectasiaHHTwho had a history of minimal epistaxis began to experience profuse epistaxis 8 to 10 weeks after starting ezetimibe-simvastatinThe patient had been treated with simvastatin 20 mg alone for 9 years without any adverse effectsTwo months after starting combination therapy with ezetimibe-simvastatin he noticed epistaxis that increased from a few drops every other day to profuse bleeding for 20 to 30 minutes dailyThe patient reported initiation of ezetimibe-simvastatin as the only change in his treatment regimen in the past yearWhen he stopped ezetimibe-simvastatinhis epistaxis decreasedAfter six weeks without ezetimibe-simvastatinhe had only one buy suhagra 100mg, buy suhagra 100mg, buy suhagra 100mg, buy suhagra 100mg, buy suhagra 100mg, buy suhagra 100mg. moderate nose bleedFour months laterthe patient’s hemoglobin was stableHe then started simvastatin 40 mg monotherapyThe profound epistaxis returned and the patient discontinued the medicationIt remains unclear whether the patient’s accelerated epistaxis was due to the combination therapy or the double dosage of simvastatinRef]
3Walker JFSimvastatinthe clinical profileAm J Med 871989s44-6.
In addition to eating a proper dietsuch as a low-cholesterol/low-fat dietother lifestyle changes that may help this medication work better include exercisinglosing weight if overweightand stopping smokingConsult your doctor for more details.
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