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Caution is needed when co-administering cilostazol with any other agent which has the potential to reduce blood naltrexone best price. pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardiaRefer also to section 4.8.
In clinical trialssmokingwhich induces CYP1A2decreased cilostazol plasma concentrations by 18
Cilostazol is extensively metabolised by CYP enzymesparticularly CYP3A4 and CYP2C19 and to mens health cialis . a lesser extent CYP1A2The dehydro metabolitewhich has 4-7 times the potency of cilostazol in inhibiting platelet aggregationappears to be formed primarily via CYP3A4The 4trans-hydroxy metabolitewith potency one-fifth that of cilostazolappears to be formed primarily via CYP2C19Thereforedrugs inhibiting CYP3A4e.gsome macrolidesazole antifungalsprotease inhibitorsor CYP2C19like proton pump inhibitorsPPIsincrease the total pharmacological activity and could have the potential to enhance the undesirable effects of cilostazolConsequentlyfor patients concomitantly taking strong CYP3A4 or CYP2C19 inhibitors the recommended dose is 50 mg twice dailysee section 4.2
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before you start taking pletal please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.