Clindamycin is a semisynthetic derivative of 7-chloro-7-deoxy lincomycin , the first-discovered member of the family, and represents the only member of lincosamines currently used in the clinical practice.
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aureus infection and may include, but is not limited to, an aminoglycoside, such as amikacin, gentamicin, kanamycin, neomycin, netilmicin, streptomycin, tobramycin or paromomycin; a carbacephem, such as loracarbef; a carbapenem, such as ertapenem, doripenem, imipenem cilastatin or meropenem; a cephalosporin, such as cefadroxil, cefazolin, cefalotin, cefalexin, cefaclor, cefamandole, cefoxitin, cefprozil, cefuroxime, cefixime, cefdinir, cefditoren, cefoperazone, cefotaxime, cefpodoxime, ceftazidime, ceftibuten, ceftizoxime, ceftriaxone, cefepime or ceftobiprole; a glycopeptide, such as teicoplanin or vancomycin; a macrolide, such as azithromycin, clarithromycin, dirithromycin, erythromycin, erythroped, roxithromycin, troleandomycin, telithromycin or spectinomycin; a monobactam, such as aztreonam; a penicillin, such as amoxicillin, ampicillin, azlocillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, mezlocillin, meticillin, nafcillin, oxacillin, penicillin, piperacillin or ticarcillin; a polypeptide, such as bacitracin, colistin or polymyxin b; a quinolone, such as ciprofloxacin, enoxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, norfloxacin, ofloxacin or trovafloxacin; a sulfonamide, such as mafenide, prontosil archaic , sulfacetamide, sulfamethizole, sulfanilamide archaic , sulfasalazine, sulfisoxazole, trimethoprim or trimethoprim-sulfamethoxazole cotrimoxazole tmp-smx ; a tetracycline, such as demeclocycline, doxycycline, minocycline, oxytetracycline or tetracycline; as well as chloramphenicol, clindamycin, lincomycin, fusidic acid, furazolidone, linezolid, metronidazole, mupirocin, nitrofurantoin, macrobid, platensimycin, quinupristin dalfopristin, rifampin or rifampicin.
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developmental toxicity studies of clindamycin performed in rats and mice using oral doses of up to 600 mg kg day 240 and 120 times amount of clindamycin in the highest recommended adult human dose based on mg m 2 , respectively or subcutaneous doses of up to 200 mg kg day 80 and 40 times the amount of clindamycin in the highest recommended adult human dose based on mg m 2 , respectively revealed no evidence of teratogenicity.
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2 software, and kinetic parameters for clindamycin s -oxidation by cyp3a4 were estimated by nonlinear regression analysis michaelis-menten equation with graphpad prism 3.
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the treatment during this period included; commencement of a gentle cleanser, a topical retinoid, topical clindamycin antibiotic , a short course of minomycin antibiotic tablets, and two 20 salicyclic acid peels.
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