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The intravenous dose will be determined by the severity of the infectionFor serious infections doses of 600 mg of lincomycin2 mL of LINCOCINto 1 gram are given every 8 to 12 hoursFor more severe infections these doses may have to be increasedIn life-threatening situations daily intravenous doses of as much as 8 grams have been givenIntravenous doses are given on the basis of 1 gram of lincomycin diluted in not less than 100 mL of appropriate solutionsee PHYSICAL COMPATIBILITIESand infused over a period of not less than one hour.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of LINCOCIN and other antibacterial drugsLINCOCIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
The serum half-life of lincomycin may be prolonged in patients with severe impairment of renal function compared to patients with normal renal functionIn patients with abnormal hepatic functionserum half-life may be twofold longer than in patients with normal hepatic function.
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