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Because Lioresal is primarily excreted unchanged through the kidneysit should be given with cautionand it may be harga salep acyclovir, harga salep acyclovir, harga salep acyclovir, harga salep acyclovir, harga salep acyclovir, harga salep acyclovir. necessary to reduce the dosage.
The lowest dose compatible with an optimal response is recommendedIf benefits are not evident after a reasonable trial periodpatients should be slowly withdrawn from the drugsee WARNINGS Abrupt Drug Withdrawal
Lioresal has been shown to increase the incidence of omphalocelesventral herniasin fetuses of rats given approximately 13 times the maximum dose recommended for human useat a dose which caused significant reductions in food intake and weight gain in damsThis abnormality was not seen in mice or rabbitsThere was also an increased incidence of incomplete sternebral ossification in fetuses of rats given approximately 13 times the maximum recommended human doseand an increased incidence of unossified phalangeal nuclei of forelimbs and hindlimbs in fetuses of rabbits given approximately 7 times the maximum recommended human doseIn miceno teratogenic effects were observedalthough reductions in mean fetal weight with consequent delays in skeletal ossification were present when dams were given 17 or 34 times the human moduretic no presciption needed. daily doseThere are no studies in pregnant womenLioresal should be used during pregnancy only if the benefit clearly justifies the potential risk to the fetus.
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