Promethazine and codeine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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because of the potential for promethazine to reverse epinephrine s vasopressor effect, epinephrine should not be used to treat hypotension associated with promethazine hydrochloride oral solution overdose.
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the impairment may be amplified by concomitant use of other central-nervous-system depressants such as alcohol, sedatives hypnotics including barbiturates , narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore such agents should either be eliminated or given in reduced dosage in the presence of promethazine hcl see precautions information for patients and drug interactions .
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