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The clearance of oxipurinol is increased by uricosuric drugsand as a consequencethe addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acidIn practicethe net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the competence of the patient’s renal function.
The clearance of oxipurinol is increased by uricosuric drugsand as a consequencethe addition of a uricosuric agent reduces to some degree the inhibition of xanthine oxidase by oxipurinol and increases to some degree the urinary excretion of uric acidIn practicethe net effect of such combined therapy may be useful in some patients in achieving minimum serum uric acid levels provided the total urinary uric acid load does not exceed the vigora 100 hindi. competence of the patient’s renal function.
The most frequent adverse reaction to Zyloprim is skin rashSkin reactions can be severe and sometimes fatalThereforetreatment with Zyloprim should be discontinued immediately if a rash developssee WARNINGSSome patients with the most severe reaction also had feverchillsarthralgiascholestatic jaundiceeosinophilia and mild leukocytosis or leukopeniaAmong 55 patients with gout treated with Zyloprim for 3 to 34 monthsaverage greater than 1 yearand followed prospectivelyRundles observed that 3of patients developed a type of drug reaction which was predominantly a pruritic maculopapular skin eruptionsometimes scaly or exfoliativeHoweverwith current usageskin reactions have been observed less frequently than 1The explanation for this decrease is not obviousThe incidence of skin rash may be increased in the presence of renal insufficiencyThe frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with Zyloprim has been reported to be increasedsee PRECAUTIONS
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