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Electron microscopy studies have demonstrated peroxisomal proliferation following fenofibrate administration to the ratAn adequate study to test for peroxisome pacific care vanuatu. proliferation in humans has not been donebut changes in peroxisome morphology and numbers have been observed in humans after treatment with other members of the fibrate class when liver biopsies were compared before and after treatment in the same individual.
When transaminase determinations were followed either after discontinuation of treatment or during continued treatmenta return to normal limits was usually observedThe incidence of increases in transaminases related to fenofibrate therapy appear to be dose relatedIn an 8-week dose-ranging studythe incidence of ALT or AST elevations to at least three times the upper limit of normal was 13in patients receiving dosages equivalent to 107 mg to 160 mg TRICOR per day and was 0in those receiving dosages equivalent to 54 mg or less TRICOR per dayor placeboHepatocellularchronic active and cholestatic hepatitis associated with fenofibrate therapy have been reported after exposures of weeks to several yearsIn extremely rare casescirrhosis has been reported in association with chronic active hepatitis.
Lipid levels should be monitored periodically and consideration should be given to reducing the dosage of TRICOR if lipid levels fall significantly below the targeted range.
TriCor is only part of a treatment program that may also include dietexerciseand weight controlFollow your doctor’s instructions very closely.
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