Dosage with sinemet cr should be substituted at an amount that provides approximately 10 more levodopa per day, although this may need to be increased to a dosage that provides up to 30 more levodopa per day depending on clinical response see titration with sinemet cr .

Information about Sinemet.
Swallow SINEMETwhole or as half tabletsonly if told by your doctorwith a glass of water.
For the reasons stated abovepatients and providers are advised to monitor for melanomas frequently and on a regular basis when using SINEMET for any indicationIdeallyperiodic skin examinations should be performed by appropriately qualified individualse.gdermatologists
Levodopa is a metabolic precursor of dopamine or a compound that participates in the chemical reaction that produces dopaminewhich is able to cross the blood-brain barrier and reach the brainwhere it can be converted to dopamine.
Caution should be exercised when the following drugs are administered concomitantly with SINEMET.
SINEMET may cause a false-positive reaction for urinary ketone bodies when a test tape is used for determination of ketonuriaThis reaction will not be altered by boiling the urine specimenFalsenegative tests may result with the use of glucose-oxidase methods of testing for united support. glucosuria.
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in abbvie s patient instructions for use, medication cassette reservoir is referred to as sinemet sr cassette.