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No adjustment to the starting dose of XELODA is recommended in patients with mild renal impairmentcreatinine clearance51 to 80 mL/minCockroft and Gaultas shown belowIn patients with moderate renal impairmentbaseline creatinine clearance30 to 50 mL/mina dose reduction to 75of the XELODA starting dose when used as real ambien 10mg without prescription. monotherapy or in combination with docetaxelfrom 1250 mg/m 2 to 950 mg/m 2 twice dailyis recommendedsee Use In Specific Populations and CLINICAL PHARMACOLOGYSubsequent dose adjustment is recommended as outlined in Table 2 and Table 3depending on the regimenif a patient develops a grade 2 to 4 adverse eventsee WARNINGS AND PRECAUTIONSThe starting dose adjustment recommendations for patients with moderate renal impairment apply to both XELODA monotherapy and XELODA in combination use with docetaxel.
Plasma protein binding of capecitabine and its metabolites is less than 60and is not concentrationdependentCapecitabine was primarily bound to human albuminapproximately 35XELODA has a low potential for pharmacokinetic interactions related to plasma protein binding.
There are no adequate and well controlled studies of XELODA in pregnant womenIf this drug is used during pregnancyor if a patient becomes pregnant while receiving XELODAthe patient should be apprised of the potential hazard to the fetusWomen boots chemist viagra cost. should be advised to avoid becoming pregnant while receiving treatment with XELODAsee WARNINGS AND PRECAUTIONS
For exampleyou may take capecitabine every day for 2 weeksThen have a week with no treatmentThen you start the cycle again.
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